Assessment of the Effects of L-Carnitine with Endurance Training After Boldenone use on Testicular Tissue Changes in Male Rats

Abstract Introduction: Researchers usually search for medications of infertility. Hence, this study was done to determine the effects of L-Carnitine and exercise on histological changes of testicular tissue after Boldenone steroid use in male rats. Objective: Assessment of the effects of L-Carnitine with Endurance training after Boldenone use on testicular tissue changes in male rats. Materials and Methods: In this interventional study, 42 male rats were randomized in control (n=7) and sham (n=7) and boldenone (n=28) groups. The boldenone group was divided into four groups. First group was sacrificed after 8 weeks. Three other groups include: Without treatment group, L-carnitine 400 mg/kg for 5 weeks and group of L-carnitine 400 mg/kg with endurance training. After preparation the histological testicular tissues were assessed using light microscope. Results: The control group had no change.  In the boldenone group with a dose of 5 mg/kg moderate changes in seminiferous and severe alterations in leydig and sertoli and spermatogenic cells were observed. Moderate changes of seminiferous and spermatogenic cells and mild alterations of sertoli and leidig cells were observed in without treatment group. Also, a mild change of spermatogenic cells in L-carnitine with endurance training group was detected. Conclusion: According to the results, it may be concluded that L-Carnitine with endurance training has proper healing effects on histological changes of testicular tissue after Boldenone use. Conflict of interest: non declared